Hamilton Morris

POD 138: Three perspectives on 7-hydroxymitragynine

In this episode I describe my own impressions on the multibillion dollar industry that has emerged around the new-ish opioid 7-hydroxymitragynine and speak with two industry insiders, Soren Shade who works as a kratom leaf vendor and policy reformer and Dr. Ahmed Alford who has studied the chemistry and pharmacology of natura...

A Fungal Fairy Tale

Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.

POD 137: Two years in an underground MDMA lab, a conversation with MethylMan

In this episode I sit down with a self-taught legend of underground MDMA synthesis and former Hive member named MethylMan. We discuss Wacker oxidation, reductive amination, aluminum amalgamation and the joys and dangers of underground chemistry.

Methyl Man's 2025-12-19 17:19:52 +0000 UTC View Post

Bufotenine: In Search of Hataj

The bufotenine episode from season three.

POD 136: [VIDEO] Patrick Phillips on the Japanese conspiracy to distribute opium laced cigarettes in China

In this episode I talk with tobacco researcher Patrick Phillips about his new book "Tobacco of the Emperor" which investigates the history of Japanese cigarettes and other tobacco products. We discuss historical claims of etorphine-laced cigarettes, the opium wars, and the curiously under-researched (at least in English?) cla...

POD 136: Patrick Phillips on the Japanese conspiracy to distribute opium laced cigarettes in China

In this episode I talk with tobacco researcher Patrick Phillips about his new book "Tobacco of the Emperor" which investigates the history of Japanese cigarettes and other tobacco products. We discuss historical claims of etorphine-laced cigarettes, the opium wars, and the curiously under-researched (at least in English?) cla...

POD 135: [VIDEO] Listening to psychedelic clinical trial participants with Becca Kacanda

In this episode I talk with MAPS phase III trial participant Becca Kacanda about her experience successfully treating PTSD with MDMA psychotherapy. The conversation covers the complexity of psychedelic psychotherapy, the importance of listening to the participants directly, and what it was like to be manipulated by Psymposia-...

POD 135: Listening to psychedelic clinical trial participants with Becca Kacanda

In this episode I talk with MAPS phase III trial participant Becca Kacanda about her experience successfully treating PTSD with MDMA psychotherapy. The conversation covers the complexity of psychedelic psychotherapy, the importance of listening to the participants directly, and what it was like to be manipulated by Psymposia-...

POD 134: [VIDEO] Lessons from Joel Stanley on Charlotte's Web

In this episode I sit down with Cannabis researcher, grower, and entrepreneur Joel Stanley to learn about the massive shift in public perception of Cannabis that occurred after the therapeutic effect of CBD on pediatric epilepsy was recognized. We also discuss legal and regulatory changes in Cannabis, the entourage effect, de...

POD 134: Lessons from Joel Stanley on Charlotte's Web

In this episode I sit down with Cannabis researcher, grower, and entrepreneur Joel Stanley to learn about the massive shift in public perception of Cannabis that occurred after the therapeutic effect of CBD on pediatric epilepsy was recognized. We also discuss legal and regulatory changes in Cannabis, the entourage eff...

Synthetic Ibogaine, Natural Tramadol

Please enjoy the ibogaine episode from season three

POD 133: [VIDEO] Dr. Andrew Gallimore on DMTx on a DMT island

This is a great and far-ranging discussion with chemist and neuroscientist Dr. Andrew Gallimore about his continuous DMT infusion project (DMTx) and his new book Death by Astonishment.

Andrew's website:
2025-10-24 21:09:02 +0000 UTC View Post

POD 133: Dr. Andrew Gallimore on DMTx on a DMT island

This is a great and far-ranging discussion with chemist and neuroscientist Dr. Andrew Gallimore about his continuous DMT infusion project (DMTx) and his new book Death by Astonishment.

Andrew Gallimore's website: 2025-10-24 18:55:31 +0000 UTC View Post

OCTOBER SUBSCRIBER Q&A, SUBMIT NOW!

Hello everybody, the subscriber Q&A returns!

Record audio of yourself asking a question (the question recording can be no more than 30 seconds) and email it to the podcast at hamiltonsresearch@gmail.com with the subject "Octo...

Synthetic Toad Venom Machine

Please enjoy the Synthetic Toad Venom Machine episode from season three, part one from season two will be uploaded soon.

ULTRA-LSD

Please enjoy the Ultra-LSD episode from season three

A Positive Methamphetamine Story

Please enjoy the methamphetamine episode from season three

POD 132: [VIDEO] DisInfoWars with Professor Dave Farina

In this episode I sat down with chemistry educator and pseudoscience debunker Dave Farina of the popular YouTube channel Professor Dave explains. We discuss the threat of disinformation, how to promote truth while reducing radicalization and polarization, wokescold-edgelord dialectics, and the rhetoric of pOwning with facts a...

POD 132: DisInfoWars with Professor Dave Farina

In this episode I sat down with chemistry educator and pseudoscience debunker Dave Farina of the popular YouTube channel Professor Dave explains. We discuss the threat of disinformation, how to promote truth while reducing radicalization and polarization, wokescold-edgelord dialectics, and the rhetoric of pOwning with facts a...

POD 131: Extended IV DMT: An interview with DMTx participant Carl Hayden Smith

In this episode I talk with DMTx test subject and psychonaut Carl Hayden Smith about his experience as a participant in Dr. Chris Timmermann's DMT infusion research at Imperial College London. The headier implications of alternate realities are explored more than I anticipated. This episode will be followed by an interview I ...

Xenon: The Perfect Anesthetic?

A few patrons requested I upload all the episodes of Hamilton's Pharmacopeia. I don't want to overwhelm the feed with episodes or make patrons feel spammed with notifications about new uploads so I will turn off notifications on these and try to upload at least one a week. Please enjoy this episode from season three. I may ed...

POD 130: BREAKING MDMA CRL with Dr. Rick Doblin

In this interview with Dr. Rick Doblin (almost one year after the last interview) we discuss the recent release of the (formerly) private letter the FDA sent to Lykos after the rejection of MDMA, which provides some additional insight into the FDA's motivations for rejecting MDMA as well as the role that Psymposia played. We ...

Synthesizing Ariadne in Alexander Shulgin's Lab

Last fall, The Shulgin Foundation invited me to film the synthesis of some compounds in Alexander Shulgin's lab in an effort to teach the public about about Shulgin's chemistry. Over two days I filmed the synthesis of ariadne and DiPT (still unfinished) and made this short doc about the experience. The final proton NMR is pos...

POD 129: Dr. Rick Doblin on FDA rejection and the future of Lykos MDMA

In this episode I visit the home of MAPS founder and president of Dr. Rick Doblin to discuss the FDA's rejection of MDMA and the future of the drug's medical development.

John Semley reports for Wired on Psymposia's secret sou...

POD 128: Dr. Daniel Panaccione on a newly discovered lysergamide producing fungus

In this episode I interview Dr. Panaccione, Professor of Plant and Soil Sciences at WVU Davis, about a newly discovered lysergamide producing fungus his student Corinne Hazel isolated from morning glory seeds and gave the wonderful name Periglandula clandestina. Additionally we discuss a fungus that was found on a sample of...

The first LSD synthesis video? A response.

Late last year mushroom educator Willy Myco released one of the strangest and most provocative chemistry videos I've ever seen, an apparent LSD synthesis tutorial filmed in Pakistan. Despite the video's ambitions—it reportedly cost $100,000 to produce—I strongly suspect that no LSD was synthesized, due to what appear to b...

POD 127: The 171.5 Million Dollar K-Hole with Stephen Watt

In this episode I spend three hours talking with the ex-hacker, anti-snitching activist, and NMDA-antagonist aficionado Stephen Watt about his experience writing computer code while high on ketamine that was used to steal millions of dollars from the cinnamon apple purveying buffet chain Boston Market, as well as T.J. Maxx an...

POD 126: The return of psychedelic selenium with Dr. Josh Hartsel

In this interview I talk with former Cybin chemist and pharmacologist Dr. Josh Hartsel about his work exploring the serotonergic structure-activity relationship of novel sulfur and selenium containing phenethylamines, his work represents the first psychedelic selenium chemistry since Shulgin's 2C-Se synthesis in PiHKAL. Read ...

Update from Spain:

Hamilton is in Spain filming a three week attempt to introduce a tellurium atom into a psychedelic molecule, he planned on releasing an interview today with Dr. Josh Hartsel but a multinational municipality issue (possibly a cyber attack?) left all of Spain without electricity, internet, or phone service. I spoke with him tod...

POD 125: An interview with Caveh Zahedi (video version!)

In this episode I visit the Brooklyn home of Caveh Zahedi, director of the films "I Am a Sex Addict" and "The Sheik and I" and talk about moralism, filmmaking, h...